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Cytochrome c oxidase present in Mitochondria have the ability to absorb OsseoPulse photons and convert this EMF energy into chemical energy (ATP)4.
The wounded tissue and bone around the implant is ischemic and hematopoetic. Precursor cells and fibroblasts have decreased ATP and decreased metabolism. OsseoPulse™ treatment delivers energy to the cells directly to increase production of ATP which accelerates wound healing and bone formation.

JT Eells et al
Mitochondrial Signal Transduction in Accelerated Wound and Retinal Healing by Near-Infrared Light Therapy
Mitochondrion 2004; 4:559–567

The documentation referred to below consists of articles and abstracts published, or accepted for publication, in scientific journals.

Accelerated Implant Stability After LED Photobiomodulation

Brawn P, Kwong-Hing A, Boeriu S and Clokie CM
J Dent Res 87(Spec Iss B):2021, 2008

Study: This article examines the effect of OsseoPulse™ treatment on implant stability, as assessed by resonance frequency analysis. 35 patients had 63 dental implants placed. 23 patients were treated with the OsseoPulse™ for 21 days. All implants were tested for primary stability with an Osstell Mentor™ at the time of implant placement, 14, 30, 60 and 90 days.

Conclusion: Patients treated with the OsseoPulse demonstrated significantly (p<0.05) improved dental implant stability at day 14, day 30 and day 60. There was a 58% reduction in time required to achieve sufficient stability to load implants compared to controls. These results may suggest that OsseoPulse treatments may allow for more rapid integration of dental implants and earlier loading.

Combined New Technologies to Improve Dental Implant Success -- Quantitative Ultrasound Evaluation of NIR-LED Photobiomodulation

Bouquot J and Brawn P
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008; 106(3):e6

Background: Dental implants must be placed in healthy bone for successful osteointegration and stability. Low bone density (LBD) and ischemically damaged, desiccated bone both have a poor ability to remodel and are, therefore, contraindications for implants. Near-infrared light emitting diode (NIR-LED) therapy or photobiomodulation has been shown in cultured cells and animal models to stimulate bone healing and production.

Study: 68 patients received 12 weeks of OsseoPulse therapy to 294 sites of ischemic/low bone density. Bone density/hydration improved by 44%, and 42% of sites returned to completely normal bone.

Conclusion: OsseoPulse therapy seems to hold good potential for improving alveolar bone prior to implant placement.

Phototherapy promotes attachment and subsequent proliferation of human osteoblast-like cells

Khadra M, Kasem N, and Brawn P
J Dent Res 87(Spec Iss B):3308, 2008

Study: The aim of the study was to investigate the effect of OsseoPulse™ treatment on attachment and proliferation of human osteoblast-like cells cultured on titanium implant material. Cells derived from human mandibular bone were exposed to OsseoPulse™ and then seeded onto titanium discs. Non-exposed cultures served as controls. Cell proliferation was determined after staining by counting cells under a light microscope. Furthermore, MTT analyses were also performed to determine cellular attachment and proliferation.

Conclusion: In this cellular model the attachment and proliferation of human osteoblast-like cells cultured on titanium implant material was significantly enhanced (p <0.05) after OsseoPulse treatment compared to controls.

Accelerated Implant Stability After LED Photobiomodulation Treatment

Brawn P, Kwong-Hing A, Aptekar A
Clin Oral Implants Res 2007; 86(2):cii

Study: 15 Nobel Biocare Replace Select implants were placed and the OsseoPulse device was utilized by the patient on a daily basis, at their home, for 21 days post operatively. Implants were tested for primarily stability with an Osstell Mentor over a period of 3 months.

The control untreated implants from Day 14 to 30 presented a typical marked loss of stability and did not reach the initial stability values at 90 days. The OsseoPulse treated group experienced a slight loss at 14 days and 30 days, but exceeded initial stability values at Day 60 and 90.

Conclusion: The accelerated implant stability of the OsseoPulse treated implants compared to the untreated controls may allow for faster healing and loading of implants that under conventional treatment regimes.  

A histologic comparison of light emitting diode phototherapy-treated hydroxyapatite-grafted extraction sockets

Brawn P, Kwong-Hing A
Implant Dent 2007; 16(2):204-11

Case Study: After bilateral extraction of periodontally involved lower molars an investigational OsseoPulse™ was used daily for 21 days on the treated side after grafting both sockets with Hydroxyapatite (HA) Osteograf LD300. Bone regeneration of the OsseoPulse™ treated and nontreated socket graft was compared. Histologic evaluations showed enhanced bone formation and faster particle resorption associated with the OsseoPulse™ treated socket graft compared with the untreated socket.

Conclusion: In this bilateral case study the accelerated bone healing in the OsseoPulse treated HA socket graft may provide faster implant placement compared to untreated treated socket grafts.

Accelerated implant stability in indirect sinus lifts with bone grafts using LED phototherapy

Kwong-Hing A, Brawn P
Proc FDI Sci 2006

Case Study: 4 bilateral implants were placed in conjunction with indirect sinus lifts grafted with Bio-Oss™ particulate. The implants were tested for primary stability at initial placement and then weekly for 4 weeks, and then at month 2 and 3.

The OsseoPulse treated implants increased stability compared to untreated controls at all time periods and achieved stability sufficient to load by the 2nd week, while the untreated controls did not reach this level of stability until after the 3rd Month.

Conclusion: The accelerated implant stability of the OsseoPulse treated implants placed with simultaneous indirect sinus lift and bone may provide faster implant stability compared untreated implants. This may allow shorter treatment times before prosthetics can be initiated.

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